Pathology of the Developing Mouse provides one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. This ebook is designed specifically to be not only a “how to do” manual for developmental pathology experimentation in mice but, more importantly, a “how to interpret” resource for pathologists and other biomedical scientists faced with defining the significance of distorted features in some fantastic murine developmental monstrosity. Key featurers include: – Baseline anatomic and physiologic traits of developing mice; – principles of good experimental design and statistical analysis for mouse developmental pathology; – procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; – methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; – and well illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal. 256 p.
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